Gallotannins in the modulation of the intestinal microbiome - Implications in chronic inflammation

With: Susanne U. Talcott, Nutrition and Food Science Department, TexasA&M University, College Station, TX, USA

Increased dietary of certain polyphenols has been associated beneficial activities in the prevention of obesity-related chronic diseases. Mango (Mangifera indica L.) contains high content of phenolic compounds (e.g., gallic acid (GA), gallotannin (GT), and galloyl glycosides), showing anti-inflammatory and antiobesogenic potential in chronic diseases. The microbial degradation of gallotannins seems to play a crucial role in their anti-inflammatory activities. Lactobacillus plantarum (L.plantarum), a probiotic member of the intestinal microbiome possesses enzymatic activities to degrade GT into GA and PG, allowing for absorption. Thus, the interaction between gut microbiota, gallotannins and absorption of gallotannin-derivatives is expected to influence the biological activities exerted by the microbial metabolites. This translational research approach investigated the potential role of the host-microbe-substrate nexus using gallotannins and L.plantarum in modulating the AMPKC/EBPα/PPARγ and AMPK-UCP1/Sirt1 as well as their potential role in modulating the intestinal microbiota in lean and obese individuals.